Lansoprazole (Lansoprazole)
Overview of Lansoprazole
Lansoprazole is an acid proton pump inhibitor. Lansoprazole is a benzimidazole sulfoxide derivarive and produces long lasting inhibition of gastric acid secretion. Lansoprazole is a chiral cmpound with one chiral center, synthsized as a racemic mixture and both enantiomers are active. Chemically Lansoprazole is identified as 2-[[[3-methyl-4-(2, 2, 2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl ]-1H-benzimidazole. Lansoprazole is effective in the treatment of duodenal or gastric ulcer, gastroesophageal reflux disease and in the treatment of zollinger-ellison syndrome. Lansoprazole is administered orally.
Indication of Lansoprazole
Lansoprazole is primarily indicated in conditions like Acid-related dyspepsia, Benign gastric ulcer, Duodenal ulcer, Duodenal ulcer associated with h. Pylori, Esophagitis, Gastric ulcer, Gastro-oesophageal reflux disease, Heart burn, Helico-bacter pylori positive duodenal ulcer, NSAID-associated gastric and duodenal ulcers, NSAID-associated gastric and duodenal ulcers (prophylaxis), NSAID-associated gastric or duodenal ulcers, Peptic ulcer, Resistant ulcers, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in GI bleeding.
Contraindication of Lansoprazole
Lansoprazole is contraindicated in conditions like Liver diseases.
Side Effects of Lansoprazole
The severe or irreversible adverse effects of Lansoprazole, which give rise to further complications include Epidermal necrolysis, Atrophic gastritis.,The symptomatic adverse reactions produced by Lansoprazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Constipation, Rashes, Pruritus.
Precautions of Lansoprazole
Lansoprazole should be used with caution in patients with any pre-existing liver disease or in case of any allergy. It should be used only if clearly needed during pregnancy or lactation. Since gastric acid secretion and other phsiological functions are decreased in elderly patients lansoprazole should be administered with caution.