Irinotecan (HCl Trihydrate) (Irinotecan (HCl Trihydrate))
Overview of Irinotecan (HCl Trihydrate)
Irinotecan (HCl Trihydrate) is an antineoplastic agent, also known as anticancer drugs. Irinotecan (HCl Trihydrate) is a semisynthetic derivative of alkaloid camptothecin. Irinotecan (HCl Trihydrate) is a pro-drug and is effective in the treatment of different cancers to slow or stop the growth of cancererous or abnormal cells. Irinotecan (HCl Trihydrate) is used in combination of different anticancer drugs to achieve best results and to reduce toxicity or side effects. It has been recently approved for clinical use.
Indication of Irinotecan (HCl Trihydrate)
Irinotecan (HCl Trihydrate) is primarily indicated in conditions like Carcinoma of colon, and can also be given in adjunctive therapy as an alternative drug of choice in Metastatic colorectal cancer.
Contraindication of Irinotecan (HCl Trihydrate)
Irinotecan (HCl Trihydrate) is contraindicated in conditions like Bone marrow failure,Bowel obstruction.
Side Effects of Irinotecan (HCl Trihydrate)
The severe or irreversible adverse effects of Irinotecan (HCl Trihydrate), which give rise to further complications include Thrombocytopenia, Neutropenia, Cholinergic crises, Diarrhea, Anaemia.,The symptomatic adverse reactions produced by Irinotecan (HCl Trihydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Anorexia, Diarrhea, Mucositis, Fever, Constipation, Sweating, Nausea and vomiting, Neutropenia, Hypersalivation, Alopecia.
Precautions of Irinotecan (HCl Trihydrate)
Irinotecan should be used with caution in patients with history, including any allergy (especially drug allergies), history of radiation treatments, diabetes, liver or lung disease. Use of laxatives should be avoided since Irinotecan may cause diarrhea. Limit alcohol intake since it may aggravate side effects. To avoid dizziness and lightheadedness, get up slowly, when rising from a seated or lying position. This drug is not recommended for use during pregnancy or lactation. Caution is advised when this drug is used in the elderly.